Nobilis Gumboro D78: Trial Data

Bursal damage: Lymphocyte depletion score

• 4 groups of SPF (specific pathogen free) chickens.
• 2 groups vaccinated with D78 at 14 days.
• 2 groups unvaccinated controls.
• All groups challenged at 28 days with recently isolated (2002) pathogenic field strains of Gumboro virus.

Morbidity and mortality following challenge

• D78 effectively prevents clinical symptoms of Gumboro Disease.
• Zero morbidity and mortality in the face of viral challenge.

Protection as evaluated by antigen capture ELISA

• Two controlled trials evaluating D78 and two competitor intermediate vaccines in broilers with maternally derived antibodies.
• Average virus neutralisation (VN) titre at time of vaccination was approximately 8 log2.
• Broilers were challenged with a virulent Gumboro virus (ref. strain F52/70).
• Efficacy was evaluated by measuring the concentration of challenge virus in the bursa 3 days post-challenge. (Birds with <1000 ELISA units/gram bursa are considered protected.)